Burden of Atopic Dermatitis

The chronic, persistent nature of atopic dermatitis (AD) means it’s always there, even when patients may appear asymptomatic.1

AD Burden: Debilitating and More Severe When Uncontrolled

  • Patients with moderate-to-severe AD report potentially debilitating signs and symptoms such as excessive itch, dryness, scaling, and open sores—all of which can lead to pain, sleep disturbance, and impaired social functioning2
  • Inadequately controlled patients had a greater physician-reported AD burden than those with controlled AD3

Inadequate Disease Control Increases
With the Severity of AD3

2014 Adelphi US Disease-Specific Program: a cross-sectional survey of physicians (n=202) and their patients (n=1064); >18 years3

Inadequate Disease Control Increases the Burden of AD3

2014 Adelphi US Disease-Specific Program: a cross-sectional survey of physicians (n=202) and their patients (n=1064); >18 years3

Understanding the difficulties that patients face is just one part of tackling this debilitating disease. Atopic dermatitis has a complex pathophysiology that drives the visible signs, symptoms, and underlying inflammation.4-6

  1. Suárez-Fariñas M, Tintle SJ, Shemer A, et al. Non-lesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities. J Allergy Clin Immunol. 2011;127(4):954-964.e1-4.
  2. Silverberg JI, Kantor R. The role of interleukins 4 and/or 13 in the pathophysiology and treatment of atopic dermatitis. Dermatol Clin. 2017;35(3):327-334.
  3. Wei W, Anderson P, Gadkari A, et al. Extent and consequences of inadequate disease control among adults with a history of moderate to severe atopic dermatitis.
    J Dermatol. 2018;45(2):150-157.
  4. Jakasa I, Verberk MM, Esposito M, Bos JD, Kezic S. Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. J Invest Dermatol. 2007;127(1):129-134.
  5. May RD, Fung M. Strategies targeting the IL-4/IL-13 axes in disease. Cytokine. 2015;75(1):89-116.
  6. Williams MR, Gallo RL. The role of the skin microbiome in atopic dermatitis. Curr Allergy Asthma Rep. 2015;15(65):1-10.