Overexpression of IL-13 in AD Skin

In 2 studies, IL-13 was found to be expressed at higher levels than IL-4 in AD skin.1,2

IL-13 Expression is Higher Than IL-4 in AD Skin1

Expression of IL-4 and IL-13 mRNA in skin samples1

Total skin samples n=28

  • IL-13 mRNA expression was present in 27/28 (96%) of skin lesions1
  • IL-4 mRNA expression was present in 3/28 (11%) of skin lesions1
    • One study showed that IL-13 was more elevated than IL-4 in AD skin; mRNA expression of IL-4 was present in 11% of AD skin lesions1

IL-13 is Overexpressed in AD Skin2

Table created by ADKeySuspect.com highlighting a study of skin samples taken from 90 patients with atopic dermatitis and 20 healthy controls to assess protein levels in lesional skin using a skin–tape stripping methodology; the data demonstrated high levels of IL-13 in all skin samples and low or undetectable IL-4 levels

  • IL-4 was detected in 41/90 (46%) patients
    • In the other study, skin samples were taken from 90 patients with AD and 20 healthy controls to assess protein levels in lesional skin using a skin–tape stripping methodology; the study demonstrated high levels of IL-13 in all skin samples and low or undetectable IL-4 levels2

These results suggest that AD is driven by IL-13 rather than by IL-41,2

A growing body of evidence supports the relative overexpression of IL-13 in AD skin; further research shows how these elevated levels relate to disease severity.3,4

  1. Tazawa T, Sugiura H, Sugiura Y, Uehara M. Relative importance of IL-4 and IL-13 in lesional skin of atopic dermatitis. Arch Dermatol Res. 2004;295(11):459-464.
  2. Koppes SA, Brans R, Ljubojevic Hadzavdic S, Frings-Dresen MH, Rustemeyer T, Kezic S. Stratum corneum tape stripping: monitoring of inflammatory mediators in atopic dermatitis patients using topical therapy. Int Arch Allergy Immunol. 2016;170(3):187-193.
  3. Tsoi LC, Rodriguez E, Degenhardt F, et al. Atopic dermatitis is an IL-13-dominant disease with greater molecular heterogeneity compared to psoriasis. J Invest Dermatol. 2019;139(7):1480-1489.
  4. Szegedi K, Lutter R, Res PC, et al. Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin. J Eur Acad Dermatol Venereol. 2015;29(11):2136-2144.